This gene encodes a member of a conserved protein family. Alternative splicing results in multiple transcript variants. This gene is thought to be associated with susceptibility to juvenile idiopathic arthritis. [provided by RefSeq, Apr 2017]
Transcription factors with Perturb-seq knockdown data for FAM177A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM177A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM177A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:34,873,262–34,875,515 | 171.1 kb | Distal (>10kb) Multiome | 1146 | |
| chr14:34,981,885–34,983,443 | 63.6 kb | Distal (>10kb) Multiome | 1124 | |
| chr14:35,045,870–35,047,118 | 9 bp | At TSS Multiome | 1047 | |
| chr14:35,121,659–35,123,040 | 75.7 kb | Distal (>10kb) Multiome | 1148 | |
| chr14:35,291,742–35,292,860 | 246.0 kb | Distal (>10kb) Multiome | 994 | |
| chr14:35,336,559–35,337,059 | 290.6 kb | Distal (>10kb) Multiome | 773 | |
| chr14:35,341,371–35,342,254 | 295.5 kb | Distal (>10kb) Multiome | 604 |
Genomic view of the FAM177A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.