Involved in regulation of cell shape and stress fiber assembly. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FAM171A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM171A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM171A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:15,088,358–15,089,070 | 282.3 kb | Distal (>10kb) Multiome | 622 | |
| chr10:15,096,597–15,098,027 | 273.8 kb | Distal (>10kb) Multiome | 949 | |
| chr10:15,167,406–15,169,756 | 202.2 kb | Distal (>10kb) Multiome | 796 | |
| chr10:15,369,657–15,370,007 | 1.1 kb | Proximal (<10kb) | 209 | |
| chr10:15,370,316–15,371,740 | 198 bp | At TSS Multiome | 451 | |
| chr10:15,472,540–15,473,626 | 102.1 kb | Distal (>10kb) Multiome | 263 |
Genomic view of the FAM171A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.