Predicted to be located in nuclear inner membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FAM169A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM169A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM169A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:74,625,689–74,626,268 | 241.0 kb | Distal (>10kb) Multiome | 148 | |
| chr5:74,631,192–74,632,778 | 235.5 kb | Distal (>10kb) Multiome | 598 | |
| chr5:74,639,680–74,641,657 | 226.1 kb | Distal (>10kb) Multiome | 999 | |
| chr5:74,684,927–74,685,413 | 181.7 kb | Distal (>10kb) Multiome | 765 | |
| chr5:74,766,697–74,767,753 | 99.8 kb | Distal (>10kb) Multiome | 976 | |
| chr5:74,865,358–74,867,179 | 681 bp | At TSS Multiome | 747 | |
| chr5:74,882,799–74,883,395 | 16.0 kb | Distal (>10kb) Multiome | 109 | |
| chr5:74,903,262–74,903,711 | 36.6 kb | Distal (>10kb) Multiome | 301 | |
| chr5:75,052,462–75,054,650 | 186.7 kb | Distal (>10kb) Multiome | 602 |
Genomic view of the FAM169A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.