This gene belongs to the FAM161 family. It is expressed mainly in the retina. Mouse studies suggested that this gene is involved in development of retinal progenitors during embryogenesis, and that its activity is restricted to mature photoreceptors after birth. Mutations in this gene cause autosomal recessive retinitis pigmentosa-28. Alternatively spliced transcript variants have been identified.[provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for FAM161A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM161A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM161A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:61,694,419–61,695,205 | 159.3 kb | Distal (>10kb) Multiome | 599 | |
| chr2:61,763,751–61,764,826 | 89.7 kb | Distal (>10kb) Multiome | 975 | |
| chr2:61,787,728–61,788,473 | 65.9 kb | Distal (>10kb) Multiome | 51 | |
| chr2:61,793,349–61,793,828 | 60.5 kb | Distal (>10kb) Multiome | 309 | |
| chr2:61,853,553–61,855,487 | 48 bp | At TSS Multiome | 973 | |
| chr2:61,888,195–61,889,300 | 34.6 kb | Distal (>10kb) Multiome | 1042 | |
| chr2:61,905,370–61,906,012 | 51.6 kb | Distal (>10kb) Multiome | 819 | |
| chr2:61,924,970–61,925,711 | 71.4 kb | Distal (>10kb) Multiome | 28 | |
| chr2:62,108,942–62,110,921 | 255.9 kb | Distal (>10kb) Multiome | 186 |
Genomic view of the FAM161A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.