Predicted to enable GTPase activator activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FAM13B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM13B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM13B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:137,735,317–137,736,260 | 297.1 kb | Distal (>10kb) Multiome | 301 | |
| chr5:137,753,755–137,755,355 | 278.5 kb | Distal (>10kb) Multiome | 1048 | |
| chr5:138,032,174–138,033,856 | 9 bp | At TSS Multiome | 889 | |
| chr5:138,036,018–138,036,514 | 3.1 kb | Proximal (<10kb) Multiome | 359 | |
| chr5:138,095,141–138,095,876 | 62.4 kb | Distal (>10kb) Multiome | 194 | |
| chr5:138,178,349–138,179,428 | 145.8 kb | Distal (>10kb) Multiome | 789 | |
| chr5:138,212,899–138,214,126 | 180.4 kb | Distal (>10kb) Multiome | 747 | |
| chr5:138,241,684–138,242,313 | 209.0 kb | Distal (>10kb) Multiome | 397 | |
| chr5:138,247,699–138,248,212 | 214.9 kb | Distal (>10kb) Multiome | 13 | |
| chr5:138,274,126–138,274,706 | 241.3 kb | Distal (>10kb) Multiome | 161 | |
| chr5:138,331,426–138,332,354 | 298.9 kb | Distal (>10kb) Multiome | 686 |
Genomic view of the FAM13B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.