Enables RNA binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FAM133B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM133B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM133B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:92,424,381–92,424,856 | 165.8 kb | Distal (>10kb) Multiome | 634 | |
| chr7:92,447,026–92,448,601 | 142.9 kb | Distal (>10kb) Multiome | 973 | |
| chr7:92,483,511–92,484,016 | 106.6 kb | Distal (>10kb) Multiome | 84 | |
| chr7:92,527,585–92,529,221 | 61.8 kb | Distal (>10kb) Multiome | 921 | |
| chr7:92,589,648–92,590,940 | 133 bp | At TSS Multiome | 1025 | |
| chr7:92,608,546–92,609,216 | 18.5 kb | Distal (>10kb) Multiome | 301 | |
| chr7:92,763,629–92,764,462 | 173.6 kb | Distal (>10kb) Multiome | 433 | |
| chr7:92,832,617–92,837,194 | 243.6 kb | Distal (>10kb) Multiome HiCAR | 1121 | |
| chr7:92,848,440–92,849,238 | 258.3 kb | Distal (>10kb) Multiome HiCAR | 136 | |
| chr7:92,880,092–92,880,930 | 290.1 kb | Distal (>10kb) Multiome | 192 | |
| chr7:93,043,277–93,044,576 | 453.3 kb | Distal (>10kb) Multiome HiCAR | 356 |
Genomic view of the FAM133B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.