Predicted to act upstream of or within sensory perception of sound. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FAM107B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM107B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM107B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:14,603,765–14,604,803 | 74 bp | At TSS Multiome | 535 | |
| chr10:14,649,147–14,650,080 | 45.3 kb | Distal (>10kb) Multiome | 36 | |
| chr10:14,737,931–14,738,710 | 134.0 kb | Distal (>10kb) Multiome | 67 | |
| chr10:14,837,437–14,839,368 | 233.9 kb | Distal (>10kb) Multiome HiCAR | 908 | |
| chr10:14,877,852–14,879,824 | 274.4 kb | Distal (>10kb) Multiome | 977 |
Genomic view of the FAM107B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.