FAF2
Fas associated factor family member 2 | ETEA, KIAA0887, UBXN3B, UBXD8

The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients. [provided by RefSeq, Jul 2008]

Member of: DE-4
Biological processes 25 terms
ERAD pathway (GO:0036503)ERAD pathway (GO:0036503)ERAD pathway (GO:0036503)VCP-NPL4-UFD1 AAA ATPase complex (GO:0034098)azurophil granule lumen (GO:0035578)cytoplasm (GO:0005737)endoplasmic reticulum (GO:0005783)endoplasmic reticulum (GO:0005783)endoplasmic reticulum (GO:0005783)endoplasmic reticulum (GO:0005783)extracellular region (GO:0005576)lipase binding (GO:0035473)lipase inhibitor activity (GO:0055102)lipid droplet (GO:0005811)lipid droplet (GO:0005811)lipid droplet organization (GO:0034389)proteasomal protein catabolic process (GO:0010498)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein binding (GO:0005515)protein-macromolecule adaptor activity (GO:0030674)retrograde protein transport, ER to cytosol (GO:0030970)stress granule disassembly (GO:0035617)ubiquitin binding (GO:0043130)ubiquitin binding (GO:0043130)ubiquitin protein ligase binding (GO:0031625)
Expression (TPM)
FAF2 — as a Regulated Gene

TFs regulating FAF2 0 TFs

Transcription factors with Perturb-seq knockdown data for FAF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to FAF2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr5:176,172,154–176,172,641 275.8 kb Distal (>10kb) Multiome 15
chr5:176,183,360–176,184,067 264.6 kb Distal (>10kb) Multiome 165
chr5:176,361,095–176,362,133 86.7 kb Distal (>10kb) Multiome 877
chr5:176,365,184–176,366,532 82.9 kb Distal (>10kb) Multiome 352
chr5:176,388,019–176,389,614 59.4 kb Distal (>10kb) Multiome 1052
chr5:176,415,859–176,416,971 31.8 kb Distal (>10kb) Multiome 827
chr5:176,440,879–176,441,157 7.2 kb Proximal (<10kb) 128
chr5:176,441,967–176,442,454 6.2 kb Proximal (<10kb) Multiome 166
chr5:176,447,162–176,449,016 153 bp At TSS Multiome 859
chr5:176,536,385–176,538,671 89.6 kb Distal (>10kb) Multiome 1006
chr5:176,541,333–176,544,229 93.3 kb Distal (>10kb) Multiome 733
chr5:176,596,638–176,597,570 148.7 kb Distal (>10kb) Multiome 234
chr5:176,609,466–176,610,727 161.7 kb Distal (>10kb) Multiome 544
chr5:176,618,956–176,619,934 171.0 kb Distal (>10kb) Multiome 328
chr5:176,630,050–176,630,816 182.1 kb Distal (>10kb) Multiome 352
chr5:176,646,726–176,648,437 199.0 kb Distal (>10kb) Multiome 701
chr5:176,660,849–176,661,318 212.6 kb Distal (>10kb) Multiome 382

Genome Browser

Genomic view of the FAF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr5:176,162,154 – 176,671,318
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
Huangfu Lab · Publications · Resources · Contact