Enables K63-linked polyubiquitin modification-dependent protein binding activity and ubiquitin-modified protein reader activity. Involved in interstrand cross-link repair and translesion synthesis. Located in cell junction; chromatin; and nuclear body. Part of Fanconi anaemia nuclear complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FAAP20. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAAP20 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAAP20, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:1,908,308–1,910,312 | 285.5 kb | Distal (>10kb) Multiome | 801 | |
| chr1:1,918,258–1,920,500 | 275.3 kb | Distal (>10kb) Multiome | 820 | |
| chr1:1,959,901–1,960,517 | 234.5 kb | Distal (>10kb) Multiome | 594 | |
| chr1:2,019,137–2,019,982 | 175.2 kb | Distal (>10kb) Multiome | 288 | |
| chr1:2,044,569–2,045,304 | 149.8 kb | Distal (>10kb) Multiome | 403 | |
| chr1:2,049,277–2,050,992 | 144.5 kb | Distal (>10kb) Multiome | 732 | |
| chr1:2,132,340–2,134,100 | 61.3 kb | Distal (>10kb) Multiome | 508 | |
| chr1:2,189,382–2,190,314 | 5.1 kb | Proximal (<10kb) Multiome | 719 | |
| chr1:2,194,502–2,195,788 | 281 bp | At TSS Multiome | 789 | |
| chr1:2,199,148–2,199,756 | 4.7 kb | Proximal (<10kb) Multiome | 445 | |
| chr1:2,204,191–2,206,396 | 10.4 kb | Distal (>10kb) Multiome | 597 | |
| chr1:2,212,255–2,213,305 | 18.0 kb | Distal (>10kb) Multiome | 601 | |
| chr1:2,226,557–2,228,163 | 33.1 kb | Distal (>10kb) Multiome | 675 | |
| chr1:2,248,086–2,248,655 | 53.7 kb | Distal (>10kb) Multiome | 296 | |
| chr1:2,279,142–2,279,636 | 84.7 kb | Distal (>10kb) Multiome | 172 | |
| chr1:2,311,328–2,311,918 | 116.9 kb | Distal (>10kb) Multiome | 366 | |
| chr1:2,314,340–2,315,728 | 120.3 kb | Distal (>10kb) Multiome | 557 | |
| chr1:2,391,076–2,392,400 | 196.9 kb | Distal (>10kb) Multiome HiCAR | 820 | |
| chr1:2,411,953–2,414,836 | 217.9 kb | Distal (>10kb) Multiome | 918 | |
| chr1:3,453,034–3,455,700 | 1260.0 kb | Distal (>10kb) Multiome HiCAR | 874 | |
| chr1:3,649,785–3,650,304 | 1455.3 kb | Distal (>10kb) Multiome HiCAR | 620 |
Genomic view of the FAAP20 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.