FAAP100 is a component of the Fanconi anemia (FA; MIM 277650) core complex and is required for core complex stability and FANCD2 (see MIM 227646) monoubiquitination (Ling et al., 2007 [PubMed 17396147]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for FAAP100. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAAP100 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAAP100, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:81,295,024–81,295,658 | 257.1 kb | Distal (>10kb) Multiome | 832 | |
| chr17:81,339,311–81,340,470 | 212.9 kb | Distal (>10kb) Multiome | 474 | |
| chr17:81,345,409–81,347,165 | 206.1 kb | Distal (>10kb) Multiome | 891 | |
| chr17:81,393,141–81,395,575 | 158.3 kb | Distal (>10kb) Multiome | 1168 | |
| chr17:81,396,480–81,397,832 | 155.0 kb | Distal (>10kb) Multiome | 646 | |
| chr17:81,481,258–81,481,865 | 70.8 kb | Distal (>10kb) Multiome | 348 | |
| chr17:81,483,927–81,484,829 | 67.9 kb | Distal (>10kb) Multiome | 828 | |
| chr17:81,487,690–81,488,371 | 64.4 kb | Distal (>10kb) Multiome | 721 | |
| chr17:81,511,887–81,515,656 | 39.5 kb | Distal (>10kb) Multiome | 1116 | |
| chr17:81,518,632–81,519,878 | 32.8 kb | Distal (>10kb) Multiome | 617 | |
| chr17:81,537,462–81,537,907 | 14.7 kb | Distal (>10kb) Multiome | 282 | |
| chr17:81,551,821–81,553,314 | 783 bp | At TSS Multiome | 845 | |
| chr17:81,636,404–81,637,301 | 84.6 kb | Distal (>10kb) Multiome | 946 | |
| chr17:81,648,048–81,648,550 | 95.9 kb | Distal (>10kb) Multiome | 88 | |
| chr17:81,652,970–81,653,572 | 100.8 kb | Distal (>10kb) Multiome | 188 | |
| chr17:81,666,251–81,667,166 | 114.3 kb | Distal (>10kb) Multiome | 901 | |
| chr17:81,683,344–81,684,556 | 131.5 kb | Distal (>10kb) Multiome | 926 | |
| chr17:81,702,879–81,703,868 | 151.0 kb | Distal (>10kb) Multiome | 981 | |
| chr17:81,711,721–81,712,812 | 159.9 kb | Distal (>10kb) Multiome | 1056 | |
| chr17:81,832,473–81,833,976 | 280.9 kb | Distal (>10kb) Multiome | 1015 |
Genomic view of the FAAP100 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.