This gene encodes a 3'-5' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for EXOSC8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EXOSC8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EXOSC8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:36,761,910–36,762,570 | 238.6 kb | Distal (>10kb) Multiome | 247 | |
| chr13:36,818,153–36,820,403 | 181.6 kb | Distal (>10kb) Multiome | 690 | |
| chr13:36,919,257–36,920,884 | 80.6 kb | Distal (>10kb) Multiome | 481 | |
| chr13:36,998,372–37,001,433 | 1.5 kb | Proximal (<10kb) Multiome | 1090 | |
| chr13:37,058,947–37,060,264 | 58.9 kb | Distal (>10kb) Multiome | 801 |
Genomic view of the EXOSC8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.