Predicted to enable RNA binding activity. Involved in DNA deamination; RNA processing; and mRNA catabolic process. Acts upstream of or within defense response to virus. Located in cytosol; euchromatin; and nuclear lumen. Part of exosome (RNase complex). [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EXOSC5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EXOSC5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EXOSC5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:41,175,862–41,176,466 | 221.2 kb | Distal (>10kb) Multiome | 330 | |
| chr19:41,192,831–41,193,504 | 204.1 kb | Distal (>10kb) Multiome | 377 | |
| chr19:41,218,771–41,219,447 | 178.3 kb | Distal (>10kb) Multiome | 345 | |
| chr19:41,262,152–41,262,839 | 134.9 kb | Distal (>10kb) Multiome | 787 | |
| chr19:41,262,983–41,265,249 | 133.3 kb | Distal (>10kb) Multiome | 1022 | |
| chr19:41,309,685–41,310,764 | 87.1 kb | Distal (>10kb) Multiome | 1016 | |
| chr19:41,324,382–41,326,571 | 72.2 kb | Distal (>10kb) Multiome | 670 | |
| chr19:41,351,173–41,351,794 | 45.9 kb | Distal (>10kb) Multiome | 465 | |
| chr19:41,352,533–41,354,401 | 43.3 kb | Distal (>10kb) Multiome | 807 | |
| chr19:41,363,475–41,364,733 | 33.3 kb | Distal (>10kb) Multiome | 774 | |
| chr19:41,376,421–41,376,995 | 20.6 kb | Distal (>10kb) Multiome | 379 | |
| chr19:41,397,079–41,398,056 | 178 bp | At TSS Multiome | 849 | |
| chr19:41,406,970–41,407,622 | 10.0 kb | Proximal (<10kb) Multiome | 88 | |
| chr19:41,426,905–41,428,213 | 30.1 kb | Distal (>10kb) Multiome | 512 | |
| chr19:41,439,463–41,440,163 | 42.4 kb | Distal (>10kb) Multiome | 765 | |
| chr19:41,548,798–41,549,566 | 151.8 kb | Distal (>10kb) Multiome | 212 | |
| chr19:41,563,228–41,563,884 | 166.2 kb | Distal (>10kb) Multiome | 419 |
Genomic view of the EXOSC5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.