Predicted to enable SH3 domain binding activity and profilin binding activity. Involved in negative regulation of epithelial cell migration; negative regulation of ruffle assembly; and positive regulation of stress fiber assembly. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EVL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EVL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EVL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:99,682,774–99,684,994 | 288.6 kb | Distal (>10kb) Multiome | 763 | |
| chr14:99,729,847–99,731,033 | 241.2 kb | Distal (>10kb) Multiome | 551 | |
| chr14:99,784,162–99,785,069 | 186.7 kb | Distal (>10kb) Multiome | 291 | |
| chr14:99,792,691–99,793,898 | 178.1 kb | Distal (>10kb) Multiome | 378 | |
| chr14:99,971,046–99,972,540 | 84 bp | At TSS Multiome | 614 | |
| chr14:100,108,167–100,108,638 | 137.0 kb | Distal (>10kb) Multiome HiCAR | 372 | |
| chr14:100,159,111–100,160,199 | 188.3 kb | Distal (>10kb) Multiome | 345 | |
| chr14:100,192,488–100,193,700 | 221.6 kb | Distal (>10kb) Multiome | 969 | |
| chr14:100,213,903–100,215,015 | 243.1 kb | Distal (>10kb) Multiome | 857 | |
| chr14:100,221,397–100,222,394 | 250.4 kb | Distal (>10kb) Multiome | 448 | |
| chr14:100,237,942–100,240,742 | 267.3 kb | Distal (>10kb) Multiome | 894 |
Genomic view of the EVL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.