Enables GTPase activator activity and small GTPase binding activity. Involved in positive regulation of GTPase activity and retrograde transport, endosome to Golgi. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EVI5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EVI5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EVI5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:92,482,022–92,487,176 | 299.2 kb | Distal (>10kb) Multiome | 917 | |
| chr1:92,784,316–92,785,703 | 109 bp | At TSS Multiome | 1089 | |
| chr1:92,786,524–92,787,008 | 1.4 kb | Proximal (<10kb) | 65 | |
| chr1:92,792,366–92,792,570 | 7.3 kb | Proximal (<10kb) | 248 | |
| chr1:92,831,415–92,832,738 | 47.0 kb | Distal (>10kb) Multiome | 1089 | |
| chr1:92,960,419–92,962,220 | 176.4 kb | Distal (>10kb) Multiome | 873 | |
| chr1:93,029,424–93,029,880 | 244.5 kb | Distal (>10kb) Multiome | 92 | |
| chr1:93,078,561–93,080,172 | 294.1 kb | Distal (>10kb) Multiome | 1219 |
Genomic view of the EVI5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.