Transcription factors with Perturb-seq knockdown data for ETS1-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ETS1-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ETS1-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:128,518,610–128,519,374 | 6.8 kb | Proximal (<10kb) | 58 | |
| chr11:128,521,715–128,523,006 | 3.1 kb | Proximal (<10kb) | 613 | |
| chr11:128,525,910–128,526,290 | at TSS | At TSS | 112 | |
| chr11:128,532,200–128,533,780 | 6.1 kb | Proximal (<10kb) | 312 |
Genomic view of the ETS1-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.