Enables enzyme inhibitor activity. Involved in respiratory electron transport chain. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ETFRF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ETFRF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ETFRF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:24,901,813–24,903,614 | 293.0 kb | Distal (>10kb) Multiome | 329 | |
| chr12:24,946,968–24,947,430 | 248.2 kb | Distal (>10kb) Multiome | 383 | |
| chr12:24,948,286–24,949,505 | 246.2 kb | Distal (>10kb) Multiome | 834 | |
| chr12:24,953,929–24,954,769 | 240.8 kb | Distal (>10kb) Multiome | 128 | |
| chr12:24,963,126–24,963,906 | 231.7 kb | Distal (>10kb) Multiome | 70 | |
| chr12:25,194,832–25,195,643 | 20 bp | At TSS Multiome | 778 | |
| chr12:25,249,926–25,251,797 | 55.9 kb | Distal (>10kb) Multiome | 848 | |
| chr12:25,384,448–25,387,046 | 191.0 kb | Distal (>10kb) Multiome | 1039 | |
| chr12:25,396,937–25,397,449 | 201.9 kb | Distal (>10kb) Multiome | 117 | |
| chr12:25,491,400–25,492,151 | 296.5 kb | Distal (>10kb) Multiome | 132 |
Genomic view of the ETFRF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.