This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for ETF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ETF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ETF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:138,247,699–138,248,212 | 295.3 kb | Distal (>10kb) Multiome | 13 | |
| chr5:138,274,126–138,274,706 | 268.9 kb | Distal (>10kb) Multiome | 161 | |
| chr5:138,331,426–138,332,354 | 211.3 kb | Distal (>10kb) Multiome | 686 | |
| chr5:138,337,358–138,339,397 | 205.1 kb | Distal (>10kb) Multiome | 1134 | |
| chr5:138,352,125–138,353,730 | 190.6 kb | Distal (>10kb) Multiome | 868 | |
| chr5:138,438,317–138,439,353 | 104.3 kb | Distal (>10kb) Multiome | 421 | |
| chr5:138,449,690–138,450,452 | 93.1 kb | Distal (>10kb) Multiome HiCAR | 486 | |
| chr5:138,463,424–138,467,199 | 78.1 kb | Distal (>10kb) Multiome HiCAR | 1117 | |
| chr5:138,489,025–138,489,656 | 53.9 kb | Distal (>10kb) Multiome | 185 | |
| chr5:138,491,730–138,492,628 | 51.1 kb | Distal (>10kb) Multiome | 627 | |
| chr5:138,542,539–138,543,997 | 91 bp | At TSS Multiome | 973 | |
| chr5:138,548,078–138,548,254 | 4.8 kb | Proximal (<10kb) | 131 | |
| chr5:138,574,967–138,576,411 | 32.5 kb | Distal (>10kb) Multiome | 1066 | |
| chr5:138,725,045–138,725,717 | 182.2 kb | Distal (>10kb) Multiome | 421 | |
| chr5:138,752,374–138,754,155 | 210.1 kb | Distal (>10kb) Multiome | 816 |
Genomic view of the ETF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.