This gene encodes a serine hydrolase that belongs to the esterase D family. The encoded enzyme is active toward numerous substrates including O-acetylated sialic acids, and it may be involved in the recycling of sialic acids. This gene is used as a genetic marker for retinoblastoma and Wilson's disease. [provided by RefSeq, Feb 2009]
Transcription factors with Perturb-seq knockdown data for ESD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ESD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ESD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:46,552,427–46,554,523 | 244.1 kb | Distal (>10kb) Multiome | 708 | |
| chr13:46,796,424–46,797,697 | 38 bp | At TSS Multiome | 930 | |
| chr13:46,893,895–46,894,720 | 97.1 kb | Distal (>10kb) Multiome | 352 | |
| chr13:48,000,679–48,002,503 | 1204.2 kb | Distal (>10kb) Multiome HiCAR | 801 | |
| chr13:48,037,295–48,039,275 | 1240.7 kb | Distal (>10kb) Multiome HiCAR | 1096 | |
| chr13:48,094,468–48,095,500 | 1298.0 kb | Distal (>10kb) Multiome HiCAR | 866 |
Genomic view of the ESD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.