Enables identical protein binding activity; protein-lysine-acetyltransferase activity; and zinc ion binding activity. Involved in peptidyl-lysine acetylation; post-translational protein acetylation; and regulation of DNA replication. Located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ESCO1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ESCO1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ESCO1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:21,344,696–21,345,449 | 255.8 kb | Distal (>10kb) Multiome | 112 | |
| chr18:21,386,651–21,387,344 | 213.9 kb | Distal (>10kb) Multiome | 145 | |
| chr18:21,599,661–21,599,837 | 1.0 kb | Proximal (<10kb) | 108 | |
| chr18:21,599,940–21,601,513 | 78 bp | At TSS Multiome | 1132 | |
| chr18:21,611,922–21,612,689 | 11.4 kb | Distal (>10kb) Multiome | 1050 | |
| chr18:21,703,851–21,705,209 | 103.9 kb | Distal (>10kb) Multiome | 801 | |
| chr18:21,740,314–21,741,964 | 139.9 kb | Distal (>10kb) Multiome | 803 | |
| chr18:21,754,780–21,755,646 | 154.3 kb | Distal (>10kb) Multiome | 105 |
Genomic view of the ESCO1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.