Predicted to be located in extracellular region and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ERVMER34-1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ERVMER34-1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ERVMER34-1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:52,657,281–52,658,511 | 93.6 kb | Distal (>10kb) Multiome | 230 | |
| chr4:52,658,663–52,660,293 | 92.2 kb | Distal (>10kb) Multiome | 590 | |
| chr4:52,711,775–52,713,336 | 39.2 kb | Distal (>10kb) Multiome | 936 | |
| chr4:52,721,591–52,722,821 | 29.2 kb | Distal (>10kb) Multiome | 629 | |
| chr4:52,743,379–52,744,025 | 7.4 kb | Proximal (<10kb) | 101 | |
| chr4:52,750,745–52,752,040 | 2 bp | At TSS Multiome | 368 | |
| chr4:52,834,642–52,835,399 | 83.4 kb | Distal (>10kb) Multiome | 83 | |
| chr4:52,861,376–52,863,512 | 110.6 kb | Distal (>10kb) Multiome HiCAR | 543 | |
| chr4:52,873,892–52,874,335 | 122.5 kb | Distal (>10kb) Multiome | 112 |
Genomic view of the ERVMER34-1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.