Enables protein-disulfide reductase activity and thiol oxidase activity. Involved in protein folding in endoplasmic reticulum. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum lumen and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for ERO1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ERO1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ERO1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:236,063,919–236,065,936 | 216.8 kb | Distal (>10kb) Multiome | 930 | |
| chr1:236,140,574–236,141,829 | 141.1 kb | Distal (>10kb) Multiome | 321 | |
| chr1:236,141,986–236,143,622 | 139.4 kb | Distal (>10kb) Multiome | 517 | |
| chr1:236,280,771–236,282,629 | 108 bp | At TSS Multiome | 881 | |
| chr1:236,287,912–236,288,026 | 6.0 kb | Proximal (<10kb) | 24 | |
| chr1:236,288,130–236,288,489 | 6.2 kb | Proximal (<10kb) | 201 | |
| chr1:236,394,885–236,396,208 | 113.5 kb | Distal (>10kb) Multiome | 588 |
Genomic view of the ERO1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.