Predicted to enable metal ion binding activity and metalloexopeptidase activity. Involved in cellular response to oxidative stress. Acts upstream of or within endoplasmic reticulum unfolded protein response. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ERMP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ERMP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ERMP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:4,489,445–4,492,426 | 1341.3 kb | Distal (>10kb) Multiome HiCAR | 545 | |
| chr9:5,628,133–5,629,918 | 204.1 kb | Distal (>10kb) Multiome | 812 | |
| chr9:5,831,978–5,833,476 | 34 bp | At TSS Multiome | 896 | |
| chr9:5,833,877–5,834,274 | 807 bp | At TSS | 27 | |
| chr9:5,885,989–5,886,773 | 53.3 kb | Distal (>10kb) Multiome | 419 | |
| chr9:6,006,744–6,008,942 | 175.3 kb | Distal (>10kb) Multiome | 899 | |
| chr9:6,015,337–6,016,019 | 182.7 kb | Distal (>10kb) Multiome | 705 | |
| chr9:6,021,445–6,021,997 | 188.7 kb | Distal (>10kb) Multiome | 90 | |
| chr9:6,049,327–6,050,383 | 217.0 kb | Distal (>10kb) Multiome | 170 | |
| chr9:6,080,023–6,081,094 | 247.4 kb | Distal (>10kb) Multiome | 455 |
Genomic view of the ERMP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.