The protein encoded by this gene contains 2 transmembrane domains near the C-terminus and is localized in the endoplasmic reticulum. Knockout of this gene in developing rat brain showed that it may be involved in neuronal migration. Mutations in this gene are associated with periventricular nodular heterotopia-6 (PVNH6). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
Transcription factors with Perturb-seq knockdown data for ERMARD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ERMARD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ERMARD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:169,619,312–169,620,680 | 131.2 kb | Distal (>10kb) Multiome | 164 | |
| chr6:169,654,626–169,655,354 | 96.8 kb | Distal (>10kb) Multiome | 165 | |
| chr6:169,656,289–169,657,223 | 94.9 kb | Distal (>10kb) Multiome | 87 | |
| chr6:169,701,339–169,702,982 | 49.5 kb | Distal (>10kb) Multiome | 1050 | |
| chr6:169,723,431–169,725,573 | 27.0 kb | Distal (>10kb) Multiome | 1078 | |
| chr6:169,751,101–169,752,286 | 19 bp | At TSS Multiome | 1057 | |
| chr6:169,789,764–169,790,892 | 38.7 kb | Distal (>10kb) Multiome | 772 | |
| chr6:169,810,281–169,811,431 | 58.9 kb | Distal (>10kb) Multiome | 326 | |
| chr6:170,006,902–170,008,105 | 255.7 kb | Distal (>10kb) Multiome | 196 |
Genomic view of the ERMARD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.