Transcription factors with Perturb-seq knockdown data for ERICH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ERICH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ERICH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:544,123–546,078 | 186.2 kb | Distal (>10kb) Multiome | 661 | |
| chr8:614,975–615,676 | 115.7 kb | Distal (>10kb) Multiome | 172 | |
| chr8:686,716–688,571 | 42.9 kb | Distal (>10kb) Multiome | 501 | |
| chr8:724,192–724,628 | 6.6 kb | Proximal (<10kb) | 85 | |
| chr8:730,654–731,828 | 69 bp | At TSS Multiome | 546 | |
| chr8:736,879–738,062 | 6.3 kb | Proximal (<10kb) Multiome | 128 | |
| chr8:738,141–739,043 | 6.9 kb | Proximal (<10kb) | 78 | |
| chr8:891,519–892,075 | 160.6 kb | Distal (>10kb) Multiome | 105 |
Genomic view of the ERICH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.