ERI1

exoribonuclease 1 | 3'HEXO, THEX1

Enables 3'-5' exonuclease activity. Involved in maturation of 5.8S rRNA. Located in cytoplasm and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-4 DE-4.13 Developmental clusters: GC7

Biological processes 26 terms

3'-5' exonuclease activity (GO:0008408)3'-5'-RNA exonuclease activity (GO:0000175)3'-5'-RNA exonuclease activity (GO:0000175)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000467)exoribonuclease II activity (GO:0008859)histone mRNA catabolic process (GO:0071044)histone pre-mRNA 3'end processing complex (GO:0071204)histone pre-mRNA stem-loop binding (GO:0071207)maturation of 5.8S rRNA (GO:0000460)negative regulation of regulatory ncRNA-mediated heterochromatin formation (GO:0060906)nucleic acid binding (GO:0003676)nucleolus (GO:0005730)nucleolus (GO:0005730)nucleolus (GO:0005730)nucleolus (GO:0005730)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)rRNA 3'-end processing (GO:0031125)rRNA binding (GO:0019843)rRNA processing (GO:0006364)ribosome binding (GO:0043022)

Expression (TPM)

TFs regulating ERI1 0 TFs

Transcription factors with Perturb-seq knockdown data for ERI1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ERI1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ERI1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ERI1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr8:8,743,546–8,744,176	259.0 kb	Distal (>10kb) Multiome HiCAR	84
chr8:8,789,557–8,790,044	213.1 kb	Distal (>10kb) Multiome HiCAR	89
chr8:8,891,982–8,894,021	109.3 kb	Distal (>10kb) Multiome	613
chr8:8,963,219–8,963,764	39.5 kb	Distal (>10kb) Multiome	278
chr8:9,002,478–9,003,402	50 bp	At TSS Multiome	894
chr8:9,057,454–9,058,557	55.2 kb	Distal (>10kb) Multiome	293
chr8:9,101,993–9,102,949	99.5 kb	Distal (>10kb) Multiome	546
chr8:9,123,903–9,124,447	121.3 kb	Distal (>10kb) Multiome	32
chr8:9,150,157–9,151,970	147.8 kb	Distal (>10kb) Multiome	725
chr8:9,183,123–9,184,864	180.7 kb	Distal (>10kb) Multiome	265
chr8:9,263,600–9,264,957	261.5 kb	Distal (>10kb) Multiome	114
chr8:9,296,640–9,298,063	294.2 kb	Distal (>10kb) Multiome	163

Genome Browser

Genomic view of the ERI1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.