ERCC3

ERCC excision repair 3, TFIIH core complex helicase subunit | BTF2, RAD25, Ssl2, XPB

This gene encodes an ATP-dependent DNA helicase that functions in nucleotide excision repair. The encoded protein is a subunit of basal transcription factor 2 (TFIIH) and, therefore, also functions in class II transcription. Mutations in this gene are associated with Xeroderma pigmentosum B, Cockayne's syndrome, and trichothiodystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Member of: DE-5

Biological processes 50 terms

3'-5' DNA helicase activity (GO:0043138)3'-5' DNA helicase activity (GO:0043138)3'-5' DNA helicase activity (GO:0043138)3'-5' DNA helicase activity (GO:0043138)3'-5' DNA helicase activity (GO:0043138)ATP binding (GO:0005524)ATP hydrolysis activity (GO:0016887)ATP hydrolysis activity (GO:0016887)DNA binding (GO:0003677)DNA binding (GO:0003677)DNA helicase activity (GO:0003678)DNA repair (GO:0006281)DNA topological change (GO:0006265)apoptotic process (GO:0006915)damaged DNA binding (GO:0003684)embryonic organ development (GO:0048568)hair cell differentiation (GO:0035315)hair cell differentiation (GO:0035315)hydrolase activity (GO:0016787)intracellular protein localization (GO:0008104)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleotide-excision repair (GO:0006289)nucleotide-excision repair (GO:0006289)nucleotide-excision repair (GO:0006289)nucleotide-excision repair factor 3 complex (GO:0000112)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of apoptotic process (GO:0043065)promoter-specific chromatin binding (GO:1990841)protein binding (GO:0005515)regulation of mitotic cell cycle phase transition (GO:1901990)response to UV (GO:0009411)response to oxidative stress (GO:0006979)transcription by RNA polymerase II (GO:0006366)transcription by RNA polymerase II (GO:0006366)transcription by RNA polymerase II (GO:0006366)transcription elongation by RNA polymerase II (GO:0006368)transcription factor TFIID complex (GO:0005669)transcription factor TFIIH core complex (GO:0000439)transcription factor TFIIH holo complex (GO:0005675)transcription factor TFIIH holo complex (GO:0005675)transcription factor TFIIH holo complex (GO:0005675)transcription initiation at RNA polymerase II promoter (GO:0006367)transcription initiation at RNA polymerase II promoter (GO:0006367)transcription initiation at RNA polymerase II promoter (GO:0006367)transcription initiation at RNA polymerase II promoter (GO:0006367)transcription preinitiation complex (GO:0097550)transcription-coupled nucleotide-excision repair (GO:0006283)transcription-coupled nucleotide-excision repair (GO:0006283)

Expression (TPM)

TFs regulating ERCC3 0 TFs

Transcription factors with Perturb-seq knockdown data for ERCC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ERCC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ERCC3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ERCC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:127,024,615–127,026,056	268.5 kb	Distal (>10kb) Multiome	462
chr2:127,049,850–127,050,796	243.8 kb	Distal (>10kb) Multiome	428
chr2:127,105,209–127,108,284	186.8 kb	Distal (>10kb) Multiome	594
chr2:127,218,704–127,220,652	74.1 kb	Distal (>10kb) Multiome	316
chr2:127,293,716–127,294,914	55 bp	At TSS Multiome	876
chr2:127,296,282–127,296,529	2.2 kb	Proximal (<10kb)	22
chr2:127,386,971–127,388,844	93.3 kb	Distal (>10kb) Multiome	986
chr2:127,407,631–127,408,983	114.0 kb	Distal (>10kb) Multiome	878
chr2:127,415,703–127,416,595	122.0 kb	Distal (>10kb) Multiome	501
chr2:127,422,503–127,423,812	129.2 kb	Distal (>10kb) Multiome	321
chr2:127,463,310–127,464,007	169.6 kb	Distal (>10kb) Multiome	176
chr2:127,525,984–127,528,084	232.5 kb	Distal (>10kb) Multiome	1026
chr2:127,542,311–127,543,476	249.1 kb	Distal (>10kb) Multiome	233
chr2:127,591,279–127,591,967	297.5 kb	Distal (>10kb) Multiome	431

Genome Browser

Genomic view of the ERCC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.