ERAL1

Era like 12S mitochondrial rRNA chaperone 1 | HERA-B

The protein encoded by this gene is a GTPase that localizes to the mitochondrion. The encoded protein binds to the 3' terminal stem loop of 12S mitochondrial rRNA and is required for proper assembly of the 28S small mitochondrial ribosomal subunit. Deletion of this gene has been shown to cause mitochondrial dysfunction, growth retardation, and apoptosis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Member of: DE-6 DE-6.17

Biological processes 22 terms

GTP binding (GO:0005525)RNA binding (GO:0003723)RNA binding (GO:0003723)RNA folding (GO:0034337)RNA folding chaperone (GO:0140691)cytosol (GO:0005829)mitochondrial inner membrane (GO:0005743)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial small ribosomal subunit assembly (GO:0180026)mitochondrion (GO:0005739)mitochondrion (GO:0005739)protein binding (GO:0005515)rRNA binding (GO:0019843)rRNA binding (GO:0019843)ribosomal small subunit assembly (GO:0000028)ribosomal small subunit assembly (GO:0000028)ribosomal small subunit binding (GO:0043024)ribosomal small subunit binding (GO:0043024)

Expression (TPM)

TFs regulating ERAL1 0 TFs

Transcription factors with Perturb-seq knockdown data for ERAL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ERAL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ERAL1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ERAL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:28,570,861–28,571,983	283.5 kb	Distal (>10kb) Multiome	701
chr17:28,576,649–28,577,524	278.0 kb	Distal (>10kb) Multiome	652
chr17:28,598,491–28,599,842	255.9 kb	Distal (>10kb) Multiome	810
chr17:28,621,936–28,622,562	232.7 kb	Distal (>10kb) Multiome	55
chr17:28,644,541–28,645,596	209.8 kb	Distal (>10kb) Multiome	795
chr17:28,661,635–28,662,527	192.9 kb	Distal (>10kb) Multiome	809
chr17:28,710,720–28,712,813	143.6 kb	Distal (>10kb) Multiome	892
chr17:28,717,030–28,718,784	137.1 kb	Distal (>10kb) Multiome	492
chr17:28,718,918–28,720,313	135.2 kb	Distal (>10kb) Multiome	927
chr17:28,724,652–28,729,474	128.0 kb	Distal (>10kb) Multiome	1286
chr17:28,743,083–28,744,926	111.0 kb	Distal (>10kb) Multiome HiCAR	991
chr17:28,745,076–28,746,436	109.4 kb	Distal (>10kb) Multiome HiCAR	568
chr17:28,749,859–28,750,549	104.8 kb	Distal (>10kb) Multiome HiCAR	550
chr17:28,811,615–28,812,945	42.5 kb	Distal (>10kb) Multiome	699
chr17:28,842,307–28,843,098	12.2 kb	Distal (>10kb) Multiome	717
chr17:28,854,460–28,855,289	105 bp	At TSS Multiome	780
chr17:28,896,962–28,898,028	42.6 kb	Distal (>10kb) Multiome	846
chr17:28,902,302–28,903,488	48.0 kb	Distal (>10kb) Multiome	967
chr17:28,950,281–28,952,708	96.6 kb	Distal (>10kb) Multiome	989
chr17:28,984,463–28,984,954	129.6 kb	Distal (>10kb) Multiome	33
chr17:28,985,971–28,986,457	131.2 kb	Distal (>10kb) Multiome	123
chr17:29,005,841–29,006,414	151.0 kb	Distal (>10kb) Multiome	707
chr17:29,039,928–29,040,500	185.2 kb	Distal (>10kb) Multiome	99
chr17:29,042,531–29,043,259	187.9 kb	Distal (>10kb) Multiome	553
chr17:29,148,688–29,149,641	294.0 kb	Distal (>10kb) Multiome	709

Genome Browser

Genomic view of the ERAL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.