This gene encodes a member of the EPS8 gene family. The encoded protein, like other members of the family, is thought to link growth factor stimulation to actin organization, generating functional redundancy in the pathways that regulate actin cytoskeletal remodeling. [provided by RefSeq, Dec 2008]
Transcription factors with Perturb-seq knockdown data for EPS8L2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EPS8L2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EPS8L2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:406,008–408,661 | 298.9 kb | Distal (>10kb) Multiome | 587 | |
| chr11:416,764–417,613 | 288.8 kb | Distal (>10kb) Multiome | 431 | |
| chr11:447,919–448,752 | 257.9 kb | Distal (>10kb) Multiome | 808 | |
| chr11:449,838–451,194 | 255.9 kb | Distal (>10kb) Multiome | 836 | |
| chr11:506,153–507,989 | 199.0 kb | Distal (>10kb) Multiome | 977 | |
| chr11:534,525–536,399 | 170.5 kb | Distal (>10kb) Multiome | 673 | |
| chr11:536,654–537,918 | 168.7 kb | Distal (>10kb) Multiome | 558 | |
| chr11:554,380–556,321 | 151.0 kb | Distal (>10kb) Multiome | 460 | |
| chr11:559,830–562,079 | 145.3 kb | Distal (>10kb) Multiome | 791 | |
| chr11:567,850–569,533 | 137.5 kb | Distal (>10kb) Multiome | 672 | |
| chr11:574,830–576,748 | 130.0 kb | Distal (>10kb) Multiome | 793 | |
| chr11:613,334–614,059 | 92.4 kb | Distal (>10kb) Multiome | 215 | |
| chr11:615,262–616,320 | 90.2 kb | Distal (>10kb) Multiome | 443 | |
| chr11:636,786–637,700 | 69.0 kb | Distal (>10kb) Multiome | 161 | |
| chr11:693,835–696,330 | 10.7 kb | Distal (>10kb) Multiome | 873 | |
| chr11:705,737–706,270 | 62 bp | At TSS Multiome | 361 | |
| chr11:706,468–707,495 | 352 bp | At TSS | 640 | |
| chr11:720,619–721,074 | 14.8 kb | Distal (>10kb) Multiome | 156 | |
| chr11:725,675–726,009 | 70 bp | At TSS | 124 | |
| chr11:726,446–726,851 | 366 bp | At TSS | 276 | |
| chr11:727,901–728,499 | 22.1 kb | Distal (>10kb) Multiome | 686 | |
| chr11:746,704–748,069 | 41.2 kb | Distal (>10kb) Multiome | 755 | |
| chr11:762,582–763,602 | 57.2 kb | Distal (>10kb) Multiome HiCAR | 326 | |
| chr11:776,216–778,328 | 71.3 kb | Distal (>10kb) Multiome | 770 | |
| chr11:783,385–783,909 | 77.6 kb | Distal (>10kb) Multiome | 278 | |
| chr11:797,112–798,675 | 92.1 kb | Distal (>10kb) Multiome | 697 | |
| chr11:804,241–805,812 | 99.2 kb | Distal (>10kb) Multiome | 725 | |
| chr11:808,894–810,402 | 103.6 kb | Distal (>10kb) Multiome | 976 | |
| chr11:818,369–820,592 | 113.4 kb | Distal (>10kb) Multiome | 749 | |
| chr11:826,980–828,116 | 121.4 kb | Distal (>10kb) Multiome | 662 | |
| chr11:828,933–831,262 | 124.3 kb | Distal (>10kb) Multiome | 491 | |
| chr11:832,323–833,565 | 126.8 kb | Distal (>10kb) Multiome | 562 | |
| chr11:842,034–843,556 | 136.6 kb | Distal (>10kb) Multiome | 794 | |
| chr11:843,773–845,220 | 138.3 kb | Distal (>10kb) Multiome | 664 | |
| chr11:849,082–850,270 | 143.7 kb | Distal (>10kb) Multiome | 229 | |
| chr11:910,337–911,591 | 204.8 kb | Distal (>10kb) Multiome | 754 | |
| chr11:925,038–926,264 | 219.7 kb | Distal (>10kb) Multiome | 689 |
Genomic view of the EPS8L2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.