This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for EPS8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EPS8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EPS8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:14,768,991–14,772,177 | 1112.5 kb | Distal (>10kb) Multiome HiCAR | 1151 | |
| chr12:15,175,208–15,176,152 | 706.6 kb | Distal (>10kb) Multiome HiCAR | 301 | |
| chr12:15,637,045–15,638,446 | 244.5 kb | Distal (>10kb) Multiome | 168 | |
| chr12:15,781,389–15,781,618 | 7.8 kb | Proximal (<10kb) | 36 | |
| chr12:15,788,278–15,790,322 | 92.9 kb | Distal (>10kb) Multiome | 987 | |
| chr12:15,794,271–15,794,473 | 4.9 kb | Proximal (<10kb) | 13 | |
| chr12:15,874,155–15,874,533 | 7.8 kb | Proximal (<10kb) | 7 | |
| chr12:15,881,783–15,883,039 | 32 bp | At TSS Multiome | 910 | |
| chr12:15,910,800–15,911,739 | 29.0 kb | Distal (>10kb) Multiome | 788 | |
| chr12:16,112,192–16,113,482 | 230.6 kb | Distal (>10kb) Multiome | 268 |
Genomic view of the EPS8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.