Enables cadherin binding activity. Predicted to be involved in endosomal transport and synaptic vesicle endocytosis. Located in membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for EPS15L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EPS15L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EPS15L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:16,184,971–16,186,029 | 286.6 kb | Distal (>10kb) Multiome | 658 | |
| chr19:16,197,472–16,198,501 | 274.1 kb | Distal (>10kb) Multiome | 806 | |
| chr19:16,247,463–16,247,928 | 224.2 kb | Distal (>10kb) Multiome | 370 | |
| chr19:16,324,466–16,326,401 | 145.8 kb | Distal (>10kb) Multiome | 477 | |
| chr19:16,471,332–16,472,638 | 99 bp | At TSS Multiome | 645 | |
| chr19:16,476,386–16,476,660 | 4.4 kb | Proximal (<10kb) | 64 | |
| chr19:16,495,870–16,496,694 | 24.3 kb | Distal (>10kb) Multiome | 780 | |
| chr19:16,541,995–16,543,080 | 70.6 kb | Distal (>10kb) Multiome | 880 | |
| chr19:16,571,833–16,572,764 | 100.5 kb | Distal (>10kb) Multiome | 814 | |
| chr19:16,627,176–16,629,209 | 156.4 kb | Distal (>10kb) Multiome | 896 | |
| chr19:16,659,555–16,661,823 | 188.2 kb | Distal (>10kb) Multiome | 987 |
Genomic view of the EPS15L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.