Transcription factors with Perturb-seq knockdown data for EPM2A-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EPM2A-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EPM2A-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:145,531,555–145,532,917 | 282.8 kb | Distal (>10kb) Multiome | 311 | |
| chr6:145,734,589–145,736,178 | 79.7 kb | Distal (>10kb) Multiome | 1204 | |
| chr6:145,813,767–145,815,849 | 13 bp | At TSS Multiome | 1126 | |
| chr6:145,815,945–145,816,140 | 1.1 kb | Proximal (<10kb) | 39 | |
| chr6:145,963,575–145,965,229 | 149.5 kb | Distal (>10kb) Multiome | 911 | |
| chr6:146,027,603–146,028,698 | 213.4 kb | Distal (>10kb) Multiome | 683 |
Genomic view of the EPM2A-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.