This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for EPHA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EPHA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EPHA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:15,975,319–15,976,269 | 180.2 kb | Distal (>10kb) Multiome | 788 | |
| chr1:16,012,632–16,013,679 | 142.9 kb | Distal (>10kb) Multiome | 615 | |
| chr1:16,026,326–16,027,360 | 129.2 kb | Distal (>10kb) Multiome | 186 | |
| chr1:16,032,851–16,033,317 | 123.0 kb | Distal (>10kb) Multiome | 349 | |
| chr1:16,048,527–16,049,209 | 107.3 kb | Distal (>10kb) Multiome | 288 | |
| chr1:16,073,117–16,073,908 | 82.5 kb | Distal (>10kb) Multiome HiCAR | 375 | |
| chr1:16,115,357–16,116,733 | 40.0 kb | Distal (>10kb) Multiome HiCAR | 269 | |
| chr1:16,145,972–16,147,046 | 9.6 kb | Proximal (<10kb) Multiome | 689 | |
| chr1:16,154,818–16,156,461 | 31 bp | At TSS Multiome | 742 | |
| chr1:16,162,474–16,162,862 | 6.4 kb | Proximal (<10kb) | 271 | |
| chr1:16,164,237–16,164,480 | 8.2 kb | Proximal (<10kb) | 515 | |
| chr1:16,167,178–16,168,479 | 11.8 kb | Distal (>10kb) Multiome | 501 | |
| chr1:16,206,128–16,208,181 | 50.7 kb | Distal (>10kb) Multiome | 760 | |
| chr1:16,212,441–16,212,918 | 56.6 kb | Distal (>10kb) Multiome | 183 | |
| chr1:16,215,805–16,218,073 | 61.5 kb | Distal (>10kb) Multiome | 490 | |
| chr1:16,226,476–16,227,566 | 70.9 kb | Distal (>10kb) Multiome | 208 | |
| chr1:16,236,291–16,237,528 | 81.1 kb | Distal (>10kb) Multiome | 717 | |
| chr1:16,351,966–16,353,171 | 196.5 kb | Distal (>10kb) Multiome | 894 | |
| chr1:16,366,922–16,368,057 | 211.2 kb | Distal (>10kb) Multiome | 957 | |
| chr1:16,440,240–16,440,992 | 284.6 kb | Distal (>10kb) Multiome | 936 |
Genomic view of the EPHA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.