This gene encodes a large coiled coil domain-containing protein that functions in autophagy during starvation conditions. Mutations in this gene cause Vici syndrome. [provided by RefSeq, Aug 2015]
Transcription factors with Perturb-seq knockdown data for EPG5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EPG5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EPG5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:45,828,904–45,829,753 | 138.0 kb | Distal (>10kb) Multiome | 246 | |
| chr18:45,837,425–45,838,195 | 129.6 kb | Distal (>10kb) Multiome | 298 | |
| chr18:45,966,885–45,967,828 | 84 bp | At TSS Multiome | 738 | |
| chr18:45,970,019–45,970,502 | 2.7 kb | Proximal (<10kb) | 79 | |
| chr18:46,071,357–46,072,732 | 104.9 kb | Distal (>10kb) Multiome HiCAR | 481 | |
| chr18:46,088,381–46,089,449 | 121.5 kb | Distal (>10kb) Multiome | 165 | |
| chr18:46,097,820–46,098,847 | 131.0 kb | Distal (>10kb) Multiome | 879 | |
| chr18:46,104,121–46,104,853 | 137.0 kb | Distal (>10kb) Multiome | 704 | |
| chr18:46,173,230–46,174,989 | 206.5 kb | Distal (>10kb) Multiome | 936 | |
| chr18:46,246,205–46,246,709 | 279.2 kb | Distal (>10kb) Multiome | 36 |
Genomic view of the EPG5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.