Involved in positive regulation of double-strand break repair via homologous recombination and regulation of cell cycle. Part of NuA4 histone acetyltransferase complex and nucleosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EPC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EPC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EPC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:148,509,278–148,509,965 | 135.1 kb | Distal (>10kb) Multiome | 703 | |
| chr2:148,554,358–148,555,153 | 90.0 kb | Distal (>10kb) Multiome | 149 | |
| chr2:148,577,566–148,579,047 | 66.4 kb | Distal (>10kb) Multiome | 183 | |
| chr2:148,643,868–148,646,256 | 545 bp | At TSS Multiome | 1053 | |
| chr2:148,813,520–148,814,415 | 169.1 kb | Distal (>10kb) Multiome | 315 | |
| chr2:148,874,671–148,877,521 | 230.4 kb | Distal (>10kb) Multiome | 652 | |
| chr2:148,998,911–149,000,002 | 354.7 kb | Distal (>10kb) Multiome HiCAR | 79 |
Genomic view of the EPC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.