Predicted to enable cytoskeletal protein binding activity and protein domain specific binding activity. Predicted to be involved in actomyosin structure organization. Predicted to act upstream of or within several processes, including chordate embryonic development; embryonic foregut morphogenesis; and mesoderm morphogenesis. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EPB41L5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EPB41L5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EPB41L5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:119,700,871–119,701,304 | 311.9 kb | Distal (>10kb) Multiome HiCAR | 92 | |
| chr2:119,702,889–119,703,364 | 310.0 kb | Distal (>10kb) Multiome HiCAR | 436 | |
| chr2:119,759,053–119,760,696 | 253.3 kb | Distal (>10kb) Multiome | 1033 | |
| chr2:119,792,781–119,793,257 | 220.0 kb | Distal (>10kb) Multiome | 152 | |
| chr2:119,996,816–119,997,661 | 15.8 kb | Distal (>10kb) Multiome | 20 | |
| chr2:120,012,388–120,013,831 | 52 bp | At TSS Multiome | 973 | |
| chr2:120,222,919–120,223,954 | 210.3 kb | Distal (>10kb) Multiome | 806 | |
| chr2:120,237,598–120,238,948 | 225.1 kb | Distal (>10kb) Multiome | 425 | |
| chr2:120,252,124–120,253,825 | 239.7 kb | Distal (>10kb) Multiome | 912 |
Genomic view of the EPB41L5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.