Predicted to be a structural constituent of cytoskeleton. Involved in several processes, including positive regulation of cell adhesion; positive regulation of keratinocyte migration; and wound healing. Acts upstream of or within actomyosin structure organization. Located in apical part of cell; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EPB41L4B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EPB41L4B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EPB41L4B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:109,118,835–109,120,627 | 201.1 kb | Distal (>10kb) Multiome | 832 | |
| chr9:109,166,465–109,167,517 | 153.9 kb | Distal (>10kb) Multiome | 131 | |
| chr9:109,316,279–109,316,627 | 4.4 kb | Proximal (<10kb) | 236 | |
| chr9:109,318,263–109,318,687 | 2.7 kb | Proximal (<10kb) Multiome | 110 | |
| chr9:109,319,189–109,321,425 | 8 bp | At TSS Multiome | 907 | |
| chr9:109,497,605–109,498,906 | 177.2 kb | Distal (>10kb) Multiome | 395 |
Genomic view of the EPB41L4B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.