ENTREP3

endosomal transmembrane epsin interactor 3 | cote1, C1orf2, FAM189B

This gene is located near the gene for the lysosomal enzyme glucosylceramidase; a deficiency in this enzyme is associated with Gaucher disease. The encoded protein has been identified as a potential binding partner of a WW domain-containing protein which is involved in apoptosis and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

Developmental clusters: GC6

Biological processes 4 terms

WW domain binding (GO:0050699)membrane (GO:0016020)nucleoplasm (GO:0005654)protein binding (GO:0005515)

Expression (TPM)

TFs regulating ENTREP3 0 TFs

Transcription factors with Perturb-seq knockdown data for ENTREP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENTREP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ENTREP3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENTREP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:154,955,571–154,956,925	299.3 kb	Distal (>10kb) Multiome	504
chr1:154,961,269–154,962,529	293.7 kb	Distal (>10kb) Multiome	985
chr1:154,970,161–154,971,641	284.6 kb	Distal (>10kb) Multiome	535
chr1:154,972,362–154,975,914	280.9 kb	Distal (>10kb) Multiome	1085
chr1:154,982,968–154,983,632	272.3 kb	Distal (>10kb) Multiome	693
chr1:154,998,961–155,004,423	256.2 kb	Distal (>10kb) Multiome	1210
chr1:155,017,084–155,017,941	238.0 kb	Distal (>10kb) Multiome	1003
chr1:155,050,292–155,052,078	204.2 kb	Distal (>10kb) Multiome	948
chr1:155,061,415–155,064,552	191.6 kb	Distal (>10kb) Multiome	860
chr1:155,070,748–155,071,423	184.4 kb	Distal (>10kb) Multiome	542
chr1:155,078,524–155,079,535	176.7 kb	Distal (>10kb) Multiome	397
chr1:155,079,852–155,081,529	174.5 kb	Distal (>10kb) Multiome	539
chr1:155,084,373–155,086,501	170.4 kb	Distal (>10kb) Multiome	865
chr1:155,091,315–155,091,900	163.9 kb	Distal (>10kb) Multiome	594
chr1:155,126,247–155,126,903	129.0 kb	Distal (>10kb) Multiome	776
chr1:155,127,607–155,128,120	127.6 kb	Distal (>10kb) Multiome	578
chr1:155,135,100–155,136,750	119.7 kb	Distal (>10kb) Multiome	938
chr1:155,166,847–155,168,170	87.7 kb	Distal (>10kb) Multiome	622
chr1:155,172,629–155,174,979	82.2 kb	Distal (>10kb) Multiome	903
chr1:155,192,921–155,194,099	61.9 kb	Distal (>10kb) Multiome	755
chr1:155,194,230–155,195,403	60.6 kb	Distal (>10kb) Multiome	753
chr1:155,196,127–155,196,592	59.1 kb	Distal (>10kb) Multiome	97
chr1:155,207,822–155,209,789	46.5 kb	Distal (>10kb) Multiome	826
chr1:155,226,522–155,227,197	28.9 kb	Distal (>10kb) Multiome	600
chr1:155,227,312–155,228,116	27.8 kb	Distal (>10kb) Multiome	688
chr1:155,244,103–155,245,349	10.7 kb	Distal (>10kb) Multiome	900
chr1:155,250,356–155,251,199	4.6 kb	Proximal (<10kb) Multiome	605
chr1:155,255,032–155,255,921	63 bp	At TSS Multiome	661
chr1:155,261,679–155,262,788	6.9 kb	Proximal (<10kb) Multiome	921
chr1:155,272,928–155,274,098	18.0 kb	Distal (>10kb) Multiome	768
chr1:155,276,933–155,278,884	23.1 kb	Distal (>10kb) Multiome	749
chr1:155,308,291–155,309,348	53.2 kb	Distal (>10kb) Multiome	934
chr1:155,320,564–155,321,470	65.4 kb	Distal (>10kb) Multiome	341
chr1:155,322,680–155,325,643	68.9 kb	Distal (>10kb) Multiome	979
chr1:155,609,731–155,610,295	354.6 kb	Distal (>10kb) Multiome HiCAR	503

Genome Browser

Genomic view of the ENTREP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.