The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq, Jan 2009]
Transcription factors with Perturb-seq knockdown data for ENTPD5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENTPD5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENTPD5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:73,718,770–73,719,334 | 300.2 kb | Distal (>10kb) Multiome | 138 | |
| chr14:73,759,247–73,760,633 | 259.0 kb | Distal (>10kb) Multiome | 912 | |
| chr14:73,771,644–73,772,269 | 247.3 kb | Distal (>10kb) Multiome | 846 | |
| chr14:73,785,281–73,785,818 | 233.8 kb | Distal (>10kb) Multiome | 458 | |
| chr14:73,786,685–73,787,517 | 232.1 kb | Distal (>10kb) Multiome | 497 | |
| chr14:73,851,491–73,852,843 | 167.4 kb | Distal (>10kb) Multiome | 842 | |
| chr14:73,886,331–73,887,426 | 132.5 kb | Distal (>10kb) Multiome | 963 | |
| chr14:73,949,767–73,950,750 | 69.1 kb | Distal (>10kb) Multiome | 932 | |
| chr14:74,018,639–74,019,694 | 17 bp | At TSS Multiome | 791 | |
| chr14:74,083,828–74,085,467 | 65.4 kb | Distal (>10kb) Multiome | 824 | |
| chr14:74,257,088–74,257,807 | 238.3 kb | Distal (>10kb) Multiome | 415 | |
| chr14:74,302,423–74,303,735 | 283.7 kb | Distal (>10kb) Multiome | 863 |
Genomic view of the ENTPD5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.