The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Transcription factors with Perturb-seq knockdown data for ENTPD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENTPD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENTPD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:95,560,414–95,561,730 | 194.3 kb | Distal (>10kb) Multiome | 707 | |
| chr10:95,655,874–95,657,154 | 99.0 kb | Distal (>10kb) Multiome | 834 | |
| chr10:95,693,285–95,694,389 | 61.7 kb | Distal (>10kb) Multiome | 744 | |
| chr10:95,840,547–95,841,469 | 85.2 kb | Distal (>10kb) Multiome | 21 | |
| chr10:95,907,059–95,908,292 | 152.2 kb | Distal (>10kb) Multiome | 823 | |
| chr10:95,920,289–95,921,295 | 164.8 kb | Distal (>10kb) Multiome | 99 | |
| chr10:96,043,065–96,044,649 | 287.8 kb | Distal (>10kb) Multiome | 891 |
Genomic view of the ENTPD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.