Transcription factors with Perturb-seq knockdown data for ENSG00000293269. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000293269 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000293269, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:64,218,636–64,219,016 | 3.3 kb | Proximal (<10kb) | 70 | |
| chr12:64,219,281–64,219,535 | 2.8 kb | Proximal (<10kb) | 64 | |
| chr12:64,221,528–64,222,890 | at TSS | At TSS | 970 | |
| chr12:64,229,328–64,229,649 | 7.0 kb | Proximal (<10kb) | 44 | |
| chr12:64,390,059–64,390,977 | at TSS | At TSS | 268 | |
| chr12:64,392,336–64,392,511 | 1.6 kb | Proximal (<10kb) | 27 | |
| chr12:64,400,113–64,400,472 | 9.4 kb | Proximal (<10kb) | 88 |
Genomic view of the ENSG00000293269 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.