Transcription factors with Perturb-seq knockdown data for ENSG00000291299. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291299 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291299, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:23,402,113–23,403,060 | 290.5 kb | Distal (>10kb) Multiome | 416 | |
| chr22:23,521,254–23,522,503 | 171.3 kb | Distal (>10kb) Multiome | 794 | |
| chr22:23,537,973–23,538,579 | 155.0 kb | Distal (>10kb) Multiome | 90 | |
| chr22:23,716,825–23,717,722 | 24.2 kb | Distal (>10kb) Multiome | 846 | |
| chr22:23,750,563–23,751,795 | 57.9 kb | Distal (>10kb) Multiome | 687 | |
| chr22:23,767,199–23,768,799 | 75.0 kb | Distal (>10kb) Multiome | 812 | |
| chr22:23,772,486–23,773,491 | 79.7 kb | Distal (>10kb) Multiome | 415 | |
| chr22:23,786,359–23,787,793 | 94.1 kb | Distal (>10kb) Multiome | 723 | |
| chr22:23,789,208–23,789,944 | 96.2 kb | Distal (>10kb) Multiome | 146 | |
| chr22:23,804,750–23,805,326 | 111.8 kb | Distal (>10kb) Multiome | 44 | |
| chr22:23,838,611–23,839,672 | 146.0 kb | Distal (>10kb) Multiome | 472 | |
| chr22:23,849,291–23,849,993 | 156.5 kb | Distal (>10kb) Multiome | 577 | |
| chr22:23,856,822–23,858,514 | 164.6 kb | Distal (>10kb) Multiome | 735 | |
| chr22:23,893,788–23,895,770 | 202.4 kb | Distal (>10kb) Multiome | 932 | |
| chr22:23,913,645–23,914,284 | 220.9 kb | Distal (>10kb) Multiome | 787 | |
| chr22:23,956,273–23,956,867 | 263.4 kb | Distal (>10kb) Multiome | 182 |
Genomic view of the ENSG00000291299 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.