Transcription factors with Perturb-seq knockdown data for ENSG00000291232. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291232 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291232, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:148,263,120–148,264,484 | 138.9 kb | Distal (>10kb) Multiome | 872 | |
| chr1:148,264,619–148,265,210 | 137.4 kb | Distal (>10kb) Multiome | 447 | |
| chr1:148,303,450–148,304,082 | 98.8 kb | Distal (>10kb) Multiome | 89 | |
| chr1:148,333,992–148,335,292 | 67.8 kb | Distal (>10kb) Multiome | 1026 | |
| chr1:148,353,276–148,354,139 | 48.8 kb | Distal (>10kb) Multiome | 234 | |
| chr1:148,384,953–148,386,164 | 16.9 kb | Distal (>10kb) Multiome | 88 | |
| chr1:148,388,031–148,389,108 | 13.7 kb | Distal (>10kb) Multiome | 719 | |
| chr1:148,402,223–148,402,924 | 53 bp | At TSS Multiome | 457 | |
| chr1:148,522,518–148,523,224 | 120.2 kb | Distal (>10kb) Multiome | 832 | |
| chr1:149,636,175–149,637,106 | 1234.0 kb | Distal (>10kb) Multiome HiCAR | 687 |
Genomic view of the ENSG00000291232 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.