Transcription factors with Perturb-seq knockdown data for ENSG00000291143. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291143 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291143, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:6,468,896–6,469,642 | 277.2 kb | Distal (>10kb) Multiome | 253 | |
| chr11:6,473,129–6,474,612 | 272.4 kb | Distal (>10kb) Multiome | 591 | |
| chr11:6,480,885–6,482,114 | 265.0 kb | Distal (>10kb) Multiome | 828 | |
| chr11:6,496,967–6,497,550 | 249.2 kb | Distal (>10kb) Multiome | 71 | |
| chr11:6,586,489–6,587,591 | 159.4 kb | Distal (>10kb) Multiome | 231 | |
| chr11:6,603,192–6,604,726 | 142.7 kb | Distal (>10kb) Multiome | 908 | |
| chr11:6,606,600–6,607,433 | 139.3 kb | Distal (>10kb) Multiome | 532 | |
| chr11:6,611,505–6,613,097 | 134.1 kb | Distal (>10kb) Multiome | 996 | |
| chr11:6,618,753–6,619,738 | 127.0 kb | Distal (>10kb) Multiome | 587 | |
| chr11:6,629,672–6,631,067 | 116.0 kb | Distal (>10kb) Multiome | 226 | |
| chr11:6,655,068–6,656,298 | 90.6 kb | Distal (>10kb) Multiome | 314 | |
| chr11:6,682,693–6,683,793 | 63.0 kb | Distal (>10kb) Multiome | 950 | |
| chr11:6,737,959–6,738,149 | 8.3 kb | Proximal (<10kb) | 85 | |
| chr11:6,755,416–6,755,643 | 9.0 kb | Proximal (<10kb) | 104 | |
| chr11:6,925,579–6,927,200 | 180.0 kb | Distal (>10kb) Multiome | 584 | |
| chr11:7,019,692–7,020,997 | 274.0 kb | Distal (>10kb) Multiome | 565 |
Genomic view of the ENSG00000291143 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.