Transcription factors with Perturb-seq knockdown data for ENSG00000291041. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291041 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291041, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:24,680,076–24,681,056 | 288.0 kb | Distal (>10kb) Multiome | 266 | |
| chr13:24,714,126–24,714,653 | 254.1 kb | Distal (>10kb) Multiome | 40 | |
| chr13:24,715,820–24,716,895 | 252.2 kb | Distal (>10kb) Multiome | 147 | |
| chr13:24,746,528–24,747,148 | 221.6 kb | Distal (>10kb) Multiome HiCAR | 140 | |
| chr13:24,922,363–24,923,209 | 45.6 kb | Distal (>10kb) Multiome | 771 | |
| chr13:24,968,393–24,968,668 | at TSS | At TSS | 10 | |
| chr13:25,047,042–25,047,668 | 78.7 kb | Distal (>10kb) Multiome | 177 | |
| chr13:25,170,532–25,171,326 | 202.4 kb | Distal (>10kb) Multiome | 133 |
Genomic view of the ENSG00000291041 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.