Transcription factors with Perturb-seq knockdown data for ENSG00000290924. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290924 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290924, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:83,817,135–83,818,401 | 1987.6 kb | Distal (>10kb) Multiome HiCAR | 350 | |
| chr9:85,522,363–85,523,393 | 282.5 kb | Distal (>10kb) Multiome | 169 | |
| chr9:85,630,543–85,631,301 | 174.5 kb | Distal (>10kb) Multiome | 65 | |
| chr9:85,723,025–85,723,722 | 81.9 kb | Distal (>10kb) Multiome | 240 | |
| chr9:85,740,973–85,742,760 | 63.3 kb | Distal (>10kb) Multiome | 834 | |
| chr9:85,804,917–85,805,981 | 35 bp | At TSS Multiome | 304 | |
| chr9:85,940,728–85,942,035 | 135.7 kb | Distal (>10kb) Multiome | 889 | |
| chr9:86,098,791–86,100,295 | 294.2 kb | Distal (>10kb) Multiome | 436 |
Genomic view of the ENSG00000290924 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.