Transcription factors with Perturb-seq knockdown data for ENSG00000290921. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290921 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290921, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:45,672,004–45,673,546 | 299.6 kb | Distal (>10kb) Multiome | 871 | |
| chr10:45,726,765–45,727,627 | 245.2 kb | Distal (>10kb) Multiome | 520 | |
| chr10:45,962,798–45,963,006 | 9.4 kb | Proximal (<10kb) | 5 | |
| chr10:45,972,130–45,972,583 | at TSS | At TSS | 358 | |
| chr10:46,023,121–46,023,829 | 51.1 kb | Distal (>10kb) Multiome | 900 | |
| chr10:46,030,064–46,031,227 | 58.2 kb | Distal (>10kb) Multiome | 853 | |
| chr10:46,047,885–46,048,755 | 76.0 kb | Distal (>10kb) Multiome | 277 | |
| chr10:46,052,126–46,053,175 | 80.2 kb | Distal (>10kb) Multiome | 517 | |
| chr10:46,106,177–46,107,298 | 134.3 kb | Distal (>10kb) Multiome | 610 | |
| chr10:46,228,286–46,229,571 | 257.1 kb | Distal (>10kb) Multiome HiCAR | 447 |
Genomic view of the ENSG00000290921 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.