Transcription factors with Perturb-seq knockdown data for ENSG00000290854. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290854 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290854, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:1,435,318–1,436,066 | 300.0 kb | Distal (>10kb) Multiome | 511 | |
| chr1:1,511,442–1,512,404 | 223.6 kb | Distal (>10kb) Multiome | 897 | |
| chr1:1,540,164–1,541,317 | 195.0 kb | Distal (>10kb) Multiome | 195 | |
| chr1:1,573,904–1,575,432 | 160.8 kb | Distal (>10kb) Multiome | 949 | |
| chr1:1,599,945–1,600,642 | 135.6 kb | Distal (>10kb) Multiome | 307 | |
| chr1:1,615,103–1,616,799 | 120.1 kb | Distal (>10kb) Multiome | 951 | |
| chr1:1,628,379–1,632,529 | 105.5 kb | Distal (>10kb) Multiome | 552 | |
| chr1:1,658,722–1,659,418 | 76.5 kb | Distal (>10kb) Multiome | 602 | |
| chr1:1,724,054–1,724,738 | 11.2 kb | Distal (>10kb) Multiome | 631 | |
| chr1:1,777,637–1,780,173 | 43.1 kb | Distal (>10kb) Multiome | 970 | |
| chr1:1,782,008–1,783,229 | 46.7 kb | Distal (>10kb) Multiome | 590 | |
| chr1:1,883,184–1,883,831 | 148.0 kb | Distal (>10kb) Multiome | 303 | |
| chr1:1,890,319–1,891,952 | 155.7 kb | Distal (>10kb) Multiome | 748 | |
| chr1:1,908,308–1,910,312 | 173.6 kb | Distal (>10kb) Multiome | 801 | |
| chr1:1,918,258–1,920,500 | 183.8 kb | Distal (>10kb) Multiome | 820 | |
| chr1:1,959,901–1,960,517 | 224.6 kb | Distal (>10kb) Multiome | 594 | |
| chr1:2,019,137–2,019,982 | 283.9 kb | Distal (>10kb) Multiome | 288 |
Genomic view of the ENSG00000290854 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.