Transcription factors with Perturb-seq knockdown data for ENSG00000290762. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290762 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290762, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:195,806,205–195,806,743 | 146.2 kb | Distal (>10kb) Multiome | 119 | |
| chr3:195,894,987–195,896,413 | 56.7 kb | Distal (>10kb) Multiome | 611 | |
| chr3:195,908,177–195,910,831 | 43.0 kb | Distal (>10kb) Multiome | 661 | |
| chr3:196,081,045–196,082,675 | 129.4 kb | Distal (>10kb) Multiome | 1081 | |
| chr3:196,110,410–196,110,962 | 157.9 kb | Distal (>10kb) Multiome | 307 | |
| chr3:196,207,804–196,208,801 | 255.5 kb | Distal (>10kb) Multiome | 300 |
Genomic view of the ENSG00000290762 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.