Transcription factors with Perturb-seq knockdown data for ENSG00000290092. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290092 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290092, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:7,430,339–7,431,763 | 445.4 kb | Distal (>10kb) Multiome HiCAR | 376 | |
| chr2:7,703,564–7,704,214 | 172.9 kb | Distal (>10kb) Multiome HiCAR | 105 | |
| chr2:7,868,348–7,869,650 | 7.0 kb | Proximal (<10kb) | 112 | |
| chr2:7,872,332–7,873,071 | 3.6 kb | Proximal (<10kb) | 71 | |
| chr2:7,876,356–7,876,899 | at TSS | At TSS | 112 | |
| chr2:7,878,298–7,879,681 | 2.5 kb | Proximal (<10kb) Multiome | 217 | |
| chr2:7,880,223–7,880,553 | 3.6 kb | Proximal (<10kb) | 15 | |
| chr2:8,582,837–8,584,915 | 707.3 kb | Distal (>10kb) Multiome HiCAR | 618 | |
| chr2:8,680,827–8,683,692 | 805.2 kb | Distal (>10kb) Multiome HiCAR | 1154 | |
| chr2:8,684,500–8,686,247 | 809.1 kb | Distal (>10kb) Multiome HiCAR | 951 |
Genomic view of the ENSG00000290092 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.