Transcription factors with Perturb-seq knockdown data for ENSG00000289529. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289529 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289529, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:58,240,694–58,241,751 | 238.4 kb | Distal (>10kb) Multiome | 963 | |
| chr2:58,312,368–58,313,254 | 166.9 kb | Distal (>10kb) Multiome | 66 | |
| chr2:58,427,459–58,429,418 | 51.0 kb | Distal (>10kb) Multiome | 520 | |
| chr2:58,434,509–58,435,726 | 44.3 kb | Distal (>10kb) Multiome | 131 | |
| chr2:58,447,649–58,448,569 | 31.5 kb | Distal (>10kb) Multiome | 351 | |
| chr2:58,479,606–58,480,048 | at TSS | At TSS | 120 | |
| chr2:58,535,035–58,535,588 | 55.7 kb | Distal (>10kb) Multiome | 228 |
Genomic view of the ENSG00000289529 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.